The Mentors

Mentors 2008-09

Kathryn Atchison

Kathryn Atchison

http://www.ph.ucla.edu/hs/bio_atchison.asp

Kathryn Atchison is a Professor in the Division of Public Health and Community Dentistry in the UCLA School of Dentistry and in the Department of Health Services, UCLA School of Public Health. Dr. Atchison has published extensively on outcomes assessment and quality of care issues, such as perceptions of oral health and development and evaluation of psychosocial outcome measures, for which she developed the Geriatric/ General Oral Health Assessment Index. Dr. Atchison serves as UCLA's Interim Vice Provost for Intellectual Property and Industry Relations. Her past administrative experience includes over four years as Associate Dean for Research & Knowledge Management for the School of Dentistry.

Fellow: Aaron Tremaine


Christian Behrenbruch

Christian Behrenbruch

http://www.linkedin.com/in/cbehrenbruch

Christian Behrenbruch is Professor in the Crump Institute for Molecular Imaging (Department of Medical and Molecular Pharmacology, David Geffen School of Medicine). His appointment as an "Entrepreneur in Residence" at UCLA follows a successful track-record in commercializing biotechnology, healthcare IT and medical devices. Dr. Behrenbruch's research focuses on the development of MEMS-based devices to accelerate antibody engineering, qualitative molecular imaging, and the "PETable Genome".

Dr. Behrenbruch is also a visiting academic at the Zhejiang-California Nanosystems Institute, Zhejiang University in Hangzhou, China and has taught entrepreneurship classes at UCLA, Oxford University, California Institute of Technology (Caltech), ESMT (Berlin), and ZJU (China).

Fellow: Aaron Tremaine


Mark J. Benedyk

Mark J. Benedyk

http://www.thepfizerincubator.com/index.html

Mark Benedyk is Head of The Pfizer Incubator LLC, a company created by Pfizer to offer scientist-entrepreneurs an opportunity to bring their medical innovations to patients. Prior to joining The Pfizer Incubator, Dr. Benedyk was Vice President of Business Development at Ascenta Therapeutics, a clinical-stage biotechnology company developing novel, pro-apoptotic small molecule drugs for the treatment of cancer. There he managed the patent estate for the company, led all contract and licensing negotiations for Ascenta, and was part of the executive team that secured $50 million for Ascenta's Series C financing.

Before coming to Ascenta, Dr. Benedyk was Vice President of Business Development and Director of Optimer Biotechnology, an international biotechnology subsidiary of Optimer Pharmaceuticals, with operations in the U.S. , Singapore and Taiwan . While there, he managed the patent estate for the company, licensed prulifloxacin, a fluoroquinoline antibiotic from Nippon Shinyaku in Japan, led business development activities for Optimer Biotechnology in Singapore, and was part of the executive team that raised $22 million for the Series C&D financing rounds for Optimer prior to its successful IPO in February of 2007.

Previously, Dr. Benedyk held business development positions at rila bioconsulting, Farmal Biomedicines, Aurora Biosciences (now Vertex Pharmaceuticals), Élan Pharmaceuticals, and Argonex Corporation. During his tenure in the pharmaceutical and biotechnology industries, Dr. Benedyk has personally led transactions worth over $300 million and participated in over $500 million worth of product licensing, corporate acquisition and fundraising transactions. Dr. Benedyk received his Ph.D. in Genetics and Developmental Biology from The Rockefeller University, where he was a Lucille P. Markey Graduate Fellow. He received his B.S. in Microbiology and Botany from the University of Michigan .

Fellow: Kathryn Nguyen


John Bowers

John Bowers

http://www.engineering.ucsb.edu/faculty/profile/139

John E. Bowers is Director of the Multidisciplinary Optical Switching Technology Center (MOST), and Professor in the Department of Electrical Engineering at the UC Santa Barbara. His research interests are primarily concerned with optoelectronic devices and optical networking. Professor Bowers is cofounder of the Center for Entrepreneurship and Engineering Management, and a cofounder of Terabit Technology and Calient Networks. He worked for AT&T Bell Laboratories and Honeywell before joining UCSB.

Dr. Bowers is a fellow of the IEEE, OSA and the American Physical Society, and a recipient of the IEEE LEOS William Streifer Award and the South Coast Business and Technology Entrepreneur of the Year Award.

Fellow: Sejal Hall


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Kent Bradford

Kent Bradford

http://www.plantsciences.ucdavis.edu/bradford/bradford.htm

Kent J. Bradford is Professor and Vice Chair for Teaching and Curriculum Development in the Department of Plant Sciences and Founding Director of the Seed Biotechnology Center at UC Davis. Dr. Bradford's research interests are in all aspects of seed biology, from the molecular biology and physiology of seed development, dormancy and germination to the storage, enhancement and utilization of seeds for agricultural purposes. His disciplinary expertise is primarily in plant water relations and the hormonal regulation of plant growth and development and more recently in plant biotechnology.

In 1999, Dr. Bradford founded and has since been director of the Seed Biotechnology Center. This is a unit of the College of Agricultural and Environmental Sciences whose mission is to mobilize the research, educational, and outreach resources of the University of California in partnership with the seed biotechnology industry to develop and commercialize new germplasm and seed technologies for agricultural and consumer benefit. The Center takes a broad view of the term "biotechnology" and does not limit it to genetic engineering. Many types of "biological technology" must be integrated in order to deliver a seed product having enhanced value to the market. Thus, in addition to genetics and breeding, improved seed production methods, enhanced seed quality, crop protection chemicals, planting technology and other requirements of seeds as multipurpose crop genetic delivery systems must also be considered. A major goal is to speed the utilization and commercialization in crop plants of information derived from basic research and model systems. The Seed Biotechnology Center's research, service and outreach activities current update on this field.

Fellow: Jamie Miller


David Brenner

David Brenner

http://som.ucsd.edu/dean

David Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at UC San Diego. In this role, Dr. Brenner leads the UC San Diego School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD Medical Center and UCSD Medical Group. He has oversight of over 900 faculty physicians, pharmacists and scientists; 7,500 staff; over 600 medical and pharmacy students, and a health system that cares for approximately 125,000 patients annually.

Dr. Brenner is a leader in the field of gastroenterological research, specializing in diseases of the liver. He is widely respected as a translational scientist whose work bridges the laboratory and clinical settings. He has focused on understanding the molecular pathogenesis of fibrotic liver disease and the genetic basis of liver disorders as the foundation for improving prevention and treatment of liver disease. He is recognized as an outstanding clinician and teacher. For five years he was Editor-in-Chief of Gastroenterology, the premier journal in the field.

He was recruited to UC San Diego from the Columbia University Medical Center College of Physicians and Surgeons, where from 2003-2007 he was Samuel Bard Professor and Chair of the Department of Medicine, a Member of the Herbert Irving Comprehensive Cancer Center, a Member of the Columbia University Institute of Nutrition, and Physician-in-Chief of New York Presbyterian Hospital/ Columbia. Prior to Columbia, Dr. Brenner was Professor and Chief of the Division of Digestive Diseases and Nutrition at the University of North Carolina at Chapel Hill.

Fellow: Kathyrn Nguyen

Laurence Brunton

Laurence Brunton

http://pharmacology.ucsd.edu/faculty/brunton.shtml

Laurence Brunton is Professor of Pharmacology and Medicine at UC San Diego. His research is focused in three areas: crosstalk among signaling systems, hormone action in the heart, and cellular effects of giardia lamblia.

Fellow: Kathyrn Nguyen



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Michael Campbell

Michael Campbell

http://sbc.ucdavis.edu/About_the_Center/SBC_Executive_Director.htm

Michael Campbell is Executive Director of the Seed Biotechnology Center at UC Davis. Michael Campbell works with Academic Director Dr. Kent Bradford to lead the ongoing development and implementation of the Center's research and education program. He oversee strategic planning and implementation of programs and activities that support SBC's mission, goals, and partnership objectives. SBC aims to serve as a link between academic research, education programs, and the commercialization of new agricultural technologies.

He became involved with the Center when it was a concept in 1998. As the Assistant Dean for College Relations, College of Agricultural and Environmental Sciences, he led the Center through the process of raising funds to build programs. He then moved to UC Merced as Associate Vice Chancellor of University Relations at UC Merced, before returning to UC Davis in his current position.

Fellow: Jamie Miller

Pam Cosman

Pam Cosman

http://www.code.ucsd.edu/~pcosman/

Pam Cosman is a Professor in the Department of Electrical and Computer Engineering, and the Co-Director of the Information Coding Laboratory at UCSD, addressing a critical challenge for high-speed Internet and mobile data transmission on how to send images at the highest speed, in the face of "noise" (interference) and limited bandwidth. The goal is to design algorithms that allow for the most compression while still maintaining acceptable video quality. She is also involved in computer vision projects in the biological sciences, including ways to analyze video to measure fish eggs, and to track and classify microscopic mutant worms.

Fellow: Nate Heintzman

Douglas Crawford

Douglas Crawford

Douglas Crawford is the Associate Executive Director of the California Institute for Quantitative Biosciences (QB3). His goal is to help stimulate economic growth in the State of California by promoting cross-discipline academic research and then accelerating the transfer of the resulting innovations to the market. He acts as a "knowledge broker" between the three QB3 campuses (UC San Francisco, Berkeley, and Santa Cruz) and the wider bio-pharmaceutical industry. He is also a Board Member of the BayBio Institute. Previously, he was the executive director of the UC San Francisco (UCSF) Innovation Accelerator, a group dedicated to stimulating entrepreneurship on the UCSF campus.

Fellow: Sarah Elson



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Mona L. Ellerbrock

Mona L. Ellerbrock

Mona Ellerbrock is Director of Corporate Relations in the Office of University Development at UC Davis. She brings to this position a deep knowledge of the UC system, and of UC Davis faculty and research in particular, as well as a strong understanding of corporate and industrial interests in higher education and research. In this position, Mona serves as a UC Davis-wide resource to deans, faculty, development officers and others to advance UC Davis' priorities through private support from corporations.

Since joining UC Davis in 1986, Mona has been at the helm of several key programs including the Environmental Hazard Management program, the Mare Island and McClellan defense conversion initiatives, Research Outreach and Industry Research Alliances. Most recently, as Director of Industry Research Alliances, Mona was part of the business development group that promoted entrepreneurship throughout UC Davis' invention and patenting portfolios and worked to expand industry partnerships with the university. She also led in the development of models and web-based communications to increase UC Davis/industry collaborations, and advocated for the integration of technology and scientific innovation in educational initiatives on the campus.

Mona Ellerbrock's professional work reflects her personal philosophy that science, technology and education, should be a force for positive change in people's lives. This philosophy has been a core focus throughout her broad experience-including installation of water pumps in dry African villages, utilizing research and education to aid in the conversion of a former military base to civilian centers for community revitalization, and creating systems to promote industry-university collaborations to support technology transfer and regional economic development. She has nearly 28 years of experience within the University of California, including a BA from UC Santa Barbara and an MPH from UC Berkeley.

Fellow: Jamie Miller

Graham Fleming Graham Fleming

http://research.chance.berkeley.edu/page.cfm?id=100

Graham Fleming is Vice Chancellor for Research and Professor of Chemistry at the University of California, Berkeley. His administrative portfolio includes management of forty campus research units, twelve research museums and remote field stations, and research administration offices including the Office of Research Administration and Compliance, Office of Intellectual Property & Industry Research Alliances (IPIRA), Research Enterprise Services, and the Office of Lab Animal Care.

Dr. Fleming, who served as Berkeley Lab's Deputy Director from 2005 through 2007, has been at the forefront of a major revolution in the biophysical sciences. Through joint appointments as Melvin Calvin Distinguished Professor of Chemistry at UC Berkeley, and Founding Director of both the Berkeley Lab's Physical Biosciences Division and UC Berkeley’s California Institute for Quantitative Biosciences (QB3), he has re-shaped the intersection of physical and biological sciences, while maintaining his own ground-breaking investigations into ultrafast chemical and biological processes, in particular, the primary steps of photosynthesis.

 

Fellow: Jasmina Allen



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Steve Gaines

Steve Gaines

http://www.lifesci.ucsb.edu/eemb/faculty/gaines/gaines_cv.pdf

Dr. Steven Gaines is Susan and Bruce Worster Acting Dean of Science, Director of the Marine Science Institute, and Professor of Ecology, Evolution, and Marine Biology and the Environmental Studies Program at UC Santa Barbara. He is a marine ecologist with ongoing research on marine conservation, the design of marine reserves, the impact of climate change on marine habitats, and the coupling between ocean circulation and the dynamics of marine species. He is a lead investigator of the PISCO project (Partnership for Interdisciplinary Studies of Coastal Oceans), a long term consortium studying marine ecosystems of the west coast of the US, the Santa Barbara Coast LTER (Long Term Ecological Research), studying connections between coastal watersheds and the ecology of kelp forests, and the Sustainable Fisheries Group, a partnership between UCSB and Environmental Defense that promotes sustainable fisheries reform using market based approaches.

Fellow: Raphael Simon



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Bernd Hamann

Bernd Hamann

http://www.cs.ucdavis.edu/people/faculty/hamann.html

Bernd Hamann is Professor in the Department of Computer Science, and Associate Vice Chancellor for Research, UC Davis. Professor Hamann was co-director of the Center for Image Processing and Integrated Computing (CIPIC), now called Institute for Data Analysis and Visualization, from 1997 to 2004. Professor Hamann specializes in visualization, geometric modeling, computer graphics, and virtual reality. His current research focus is the development of hierarchical representation and visualization methods for use in interactive exploration of massive data sets. Professor Hamann received an NSF Research Initiation Award in 1992 and an NSF CAREER Award in 1996. He was a member of the Editorial Board of the IEEE Transactions on Visualization and Computer Graphics and served as a papers co-chair and proceedings co-editor of the annual IEEE Visualization conferences in 1999 and 2000.

Fellow: Amy Gryshuk



Regis Kelly

Regis Kelly

http://pub.ucsf.edu/missionbay/science/kelly_qb3.php

Regis Kelly is Executive Director of the California Institute for Quantitative Sciences (QB3), at UCSF, UC Berkeley, and UC Santa Cruz. Prior to his appointment at QB3, Kelly served as Executive Vice Chancellor of UCSF, overseeing the UCSF research enterprise, which now totals about $465 million annually. Earlier, he was Chair of Biochemistry and Biophysics. One of his major research efforts focused on proteins that allow neurotransmitters to be released quickly and efficiently from nerve terminals in the synapse. The proteins are involved in long term memory.

Fellow: Sarah Elson



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Anantha Krishnan

Anantha Krishnan

https://www-eng.llnl.gov/bios/bios_krishnan.html

Dr. Anantha Krishnan is the Director of R&D for Meso-, Micro- and Nano-Technology in the Engineering Directorate at Lawrence Livermore National Laboratory (LLNL). He manages a group of scientists as well as a fabrication facility dedicated to the areas of advanced micro-/nano-fabrication and advanced sensor devices/systems for mechanical, optical, chemical and biological sensing and detection.

Dr. Krishnan was a Program Manager at DARPA from 1999 to 2005. He managed several programs in the area of nano-bio-technology for the Defense Sciences Office as well as programs in the area of high performance microelectronic circuit design for the Microsystems Technology Office. From 1989 to 1999, Dr. Krishnan held various positions, including Vice-President for Advanced Technology, at Computational Fluid Dynamics Research Corporation (CFDRC) where he managed several projects in the areas of semiconductor processing technology, MEMS/bio-MEMS, supercritical fluid technology, crystal growth and aerospace/rocket propulsion

Dr. Krishnan obtained his doctoral degree (in Mechanical Engineering) from the Massachusetts Institute of Technology in 1989. He has more than 60 publications in international journals and conferences.

Fellow: Satinderpall S. Pannu

 

Diana Leite

Diana Leite is Assistant Vice Chancellor for Research Enterprise Services at UC Berkeley.

[More information to follow.]

Fellow: Jasmina Allen

G.P. Li

G.P. Li

http://www.eng.uci.edu/user/81

G.P. Li is Professor of Electrical Engineering and Computer Science, Professor of Biomedical Engineering, Director of the California Institute for Telecommunications and Information Technology, and Director of the Integrated Nanosystems Research Facility, UC Irvine. Dr. Li is interested in high-speed semiconductor technology, micro-electro-mechanical systems (MEMS) technology, opto-electronic devices, and the design, fabrication and testing of integrated circuits. Dr. Li's current research activities focus on the development of novel materials and processes for the fabrication of high-speed electronic and opto-electronic devices to be used in network and wireless communication applications. Another area of his research involves novel electro-optical probing of semiconductor materials, devices and circuits for in-situ wafer quality evaluation. Dr. Li is also investigating ultra-high-speed chip level testing, design and fabrication of novel electronic/optoelectronic devices for low power technology, and the design and fabrication of novel MEMS devices for bio-medical and sensing applications.

Fellow: Paul Marc

Ira Lott

Ira Lott

http://www.ucihs.uci.edu/pediatrics/faculty/neurology/lott/lott.html

Ira Lott is Professor of Pediatrics, Chief of Pediatric Neurology Division, Professor of Neurology, Associate Dean of Clinical Neurosciences, and Director of Neurosciences Development, UCI Health Systems at UC Irvine School of Medicine. Professor Lott was Chairman of UC Irvine's Department of Pediatrics from 1990-2000, and since 2000, he has served at UCI as Associate Dean of Clinical Neuroscience. Dr. Lott's primary research interest is in the neurology of developmental disabilities. He is the director of the Scientific Advisory Board of the National Down Syndrome Society in New York.

Fellow: Paul Marc



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Pat Mantey

Pat Mantey

http://www.cs.ucsc.edu/~mantey/

Professor Patrick E. Mantey is the founding Dean of the Jack Baskin School of Engineering for UC Santa Cruz. He is now the director of ITI, the Information Technology Institute in the Baskin School of Engineering. Professor Mantey is a Fellow of the Institute of Electrical and Electronics Engineers and a member of American Society for Engineering Education. He is the UC Santa Cruz affiliate director of CITRIS, serves on the Steering Committee of the UC Industry University Cooperative Research Program, and is a scientific advisor to Rockliff.

His research interests include image storage and retrieval, electronic libraries and multimedia, educational applications of computer technology, image and signal processing, graphics and workstation hardware, system architecture, design, and performance, simulation and modeling of complex systems, real-time data acquisition and control systems, graphics and database applications, including geographic information systems, and human-computer interaction.

Fellow: Bradley Smith

Dennis Matthews

Dennis Matthews

http://cbst.ucdavis.edu/people/dlmatthe/dennis-l-matthews-ph-d

Dr. Matthews is the Director of the Center for Biophotonics Science and Technology at UC Davis. He also holds a joint appointment at UC Davis College of Engineering and School of Medicine, is the Program Leader of the Medical Technology Program at Lawrence Livermore National Laboratory, and an Associate Director at the UC Davis Integrated Cancer Program. An expert on the radiative properties of ions in plasmas as well as in the conversion of laser light into X-rays, Dr. Matthews is widely acknowledged to have invented and developed the x-ray wavelength lasers.

Fellows: Amy Gryshuk, Gabriela Lee, Satinderpall S. Pannu

Dennis Matthews

David McGee

http://www.innovationaccess.ucdavis.edu/home.cfm

David McGee is Executive Director of UC Davis InnovationAccess, where he is responsible for the management of UC Davis' intellectual property, including discoveries, patent filings, and licensing activities, as well as establishing new companies based on university technologies and promoting UC Davis as a world leader in innovation.

Dr. McGee has over twenty years of senior management experience in the biotechnology industry. He was co-founder and, for 16 years, executive vice president of the Large Scale Biology Corporation, a publicly traded biotechnology company that develops biopharmaceuticals for human health care and veterinary medicine. Prior to that Dr. McGee was vice president of operations at Sungene Technologies, Inc., an agriculture biotechnology company that developed new commercial traits in major crop species. During his career, McGee has managed sizeable patent portfolios, as well overseeing major research programs in drug discovery and plant functional genomics.

Fellow: Gabriela Lee

Don Oparah

Don Oparah

http://www.vai.ucsb.edu/about-us/team

Don Oparah is the Founding Director of the Venture Acceleration Initiative at UC Santa Barbara. Don provides leadership, direction and motivation to the VAI team, acts as an evangelist to and secures support and resources from the external community, develops strategic partnerships, and works actively with a growing number of promising campus ventures.

Don initially joined UC Santa Barbara in 2006 as a UC Discovery Fellow and developed the vision and concept for the Venture Acceleration Initiative working closely with the Deans of Engineering and Science and other campus leaders. Don received his PhD in Computer Science at Cambridge before working in IT and Strategy consulting for four years. Most recently he completed his MBA at UCLA Anderson School of Management with a focus on Entrepreneurship.

Fellow: Sejal Hall

Bhaskar Rao

Bhaskar Rao

http://www.jacobsschool.ucsd.edu/faculty/faculty_bios/findprofile.pl?fmp_recid=56

Bhaskar Rao is Professor of Electrical and Computer Engineering, and Director of the Center for Wireless Communications at UC San Diego. Professor Rao's research interests are in the areas of digital signal processing, estimation theory, and optimization theory, with applications to digital communications, speech signal processing, and human-computer interactions.

Professor Rao and his research group have received six paper awards in the last eight years with the most recent being the 2008 Stephen O. Rice Prize Paper Award in the Field of Communications Systems jointly with Bongyong Song and Rene Cruz. In May 2008, Rao was named the inaugural holder of the Ericsson Endowed Chair in Wireless Access Networks in the Jacobs School of Engineering at UC San Diego.

Fellow: Nate Heintzman

Ramesh Rao

Ramesh Rao

http://fleece.ucsd.edu/faculty_pages/rrao.html

Ramesh Rao is Director of the UCSD Division of Calit2, and Professor of Electrical and Computer Engineering at UCSD. Professor Rao previously served as the Director of the UCSD Center for Wireless Communications (CWC) and as the Vice Chair of Instructional Affairs in the Department of Electrical and Computer Engineering.

Professor Rao's research interests include architectures, protocols and performance analysis of wireless, wire line and photonic networks for integrated multi-media services. He has also consulted extensively for Government agencies and industry. He has served on a US Government panel to review the current status of research, development, and applications in wireless communications in the United States, Japan, and Western Europe with a view towards evaluating the competitive status of U.S. efforts.

Fellow: Nate Heintzman



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Paul Siegel

Paul Siegel

http://vivaldi.ucsd.edu:8080/~psiegel/

Paul H. Siegel is Professor of Electrical and Computer Engineering at UCSD. He is affiliated with the California Institute of Telecommunications and Information Technology (Calit2), the Center for Wireless Communications (CWC), and the Center for Magnetic Recording Research (CMRR), where he holds an endowed chair and currently serves as Director.

His primary research interest is the mathematical foundations of signal processing and coding, especially as applicable to digital data storage and communications. He holds several patents in the area of coding and detection for digital recording systems, and was named a Master Inventor at IBM Research in 1994. He was elected to the National Academy of Engineering in 2008, "for the invention and development of advanced coding techniques for digital recording systems."

Fellow: Nate Heintzman

Tod Stolz

Tod Stolz

Tod Stoltz is Industry Relations Officer at the Center for Biophotonics Science and Technology (CBST), UC Davis Medical Center. He leads the development of a business plan for how the Center will operate after its NSF funding ends in 2012, and he expands and seeks to improve interactions between the Center and industry.

Prior to joining CBST, Todd started Technology Business Development, a new unit at the UC Davis Medical Center, whose mission is to commercialize new medical technology developed at UC Davis. In 1994, he helped move a technology out of UC Davis into a new company called Applied Phytologics, Inc. He became the first employee at API and worked there for nine years. API, now called Ventria Bioscience, is one of the leading companies in the emerging Plant-Made Pharmaceutical business.

Fellows: Amy Gryshuk, Gabriela Lee

Robert Sullivan

Robert Sullivan

http://management.ucsd.edu/about/dean/

Robert S. Sullivan, founding Dean of UCSD's Rady School of Management, is an internationally acclaimed expert on entrepreneurship, knowledge management, operations and venture financing. In addition to serving as Dean, he is the Stanley and Pauline Foster Endowed Chair. Prior to his arrival at UCSD, Dr. Sullivan served as dean of UNC's Kenan-Flagler Business School. He initiated a weekend executive MBA Program that was ranked 5th in the world by Business Week magazine in 2001. He also launched the OneMBA executive MBA program, the first truly global program delivered in partnership with four other top-tier international business schools.

Fellow: Lada Rasochova



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Palmer Taylor

Palmer Taylor

http://pharmacology.ucsd.edu/faculty/taylor_p.shtml

Palmer Taylor is Professor of Pharmacology, Dean, Skaggs School of Pharmacy & Pharmaceutical Sciences, and Associate Vice Chancellor for Health Sciences at UC San Diego. Dr. Taylor's research has been directed to the structures, recognition capacities and regulation of expression of proteins governing neurotransmission in cholinergic synapses. His group cloned the first acetylcholinesterase (AChE) gene over 20 years ago, and this was followed by analysis of its genomic DNA to delineate regulatory regions, the multiple splicing options and gene expression profiles in nerve and muscle. His studies of AChE structure and its complexes by crystallographic and fluorescence methods, characterizing a peripheral site on AChE and the demonstrating flexibility of the active center gorge, provided the basis for collaborative studies with Barry Sharpless' group employing freeze-frame, click chemistry. The very biological target itself (AChE) is used as the template in the synthesis of high affinity, selective inhibitors. Taylor's long standing work with nicotinic acetylcholine receptors (nAChR) defined ligand specificity in relation to state functions for receptor activation and desensitization and identified the structural determinants on nAChR governing ligand and peptide toxin specificity.

More recently, his studies have been directed to the acetylcholine binding protein, a soluble surrogate of the receptor, whereby his group in collaboration with others, employed physical methods of fluorescence anisotropy decay, NMR, x-ray crystallography and denterium hydrogen exchange to examine structure and selectivity of the ligand binding sites. Finally, through collaborative endeavors, Taylor 's group have uncovered much of what is known about the structure of neuroligin, a synaptic adhesion molecule homologous to AChE. Their structural studies on neuroligin have uncovered alterations in processing and folding associated with mutations found in the autistic spectral disorders.

Fellow: Kathryn Nguyen


Matt Tirrell

Matt Tirrell

http://www.chemengr.ucsb.edu/~ceweb/faculty/tirrell/resume.htm

Dr. Matthew Tirrell is the Richard A. Auhll Professor of Engineering and the Dean of the College of Engineering at UC Santa Barbara. From 1977 to 1999 Tirrell was on the faculty of Chemical Engineering and Materials Science at the University of Minnesota, where he served as head of the department from 1995 to 1999. His research has been in polymer surface properties including adsorption, adhesion, surface treatment, friction, lubrication and biocompatibility. He has co-authored about 250 papers and one book and has supervised about 60 Ph.D. students. Tirrell's research is focused on the manipulation and measurement of interfacial properties of materials used in applications from coatings and adhesion to lubrication and bioengineering.

Fellows: Sejal Hall, Raphael Simon


George R. Tynan

George R. Tynan

http://tynan-pc.ucsd.edu/

George R. Tynan is Associate Vice Chancellor for Research and Professor of Mechanical and Aerospace Engineering at UC San Diego. He received his Ph.D. in 1991 from the Department of Mechanical, Aerospace, and Nuclear Engineering at the University of California, Los Angeles. He then spent several years studying the effect of sheared flows on plasma turbulence on experiments in the Federal Republic of Germany and at Princeton Plasma Physics Laboratory. He returned to UCLA and helped develop a concept for a new fusion experiment currently under construction. He joined the UC San Diego faculty in July 1999 after spending several years investigating the application of low-temperature plasmas to the creation of nano-meter scale semiconductor circuits. His current research interests include basic studies of plasma turbulence and transport, low-temperature plasma physics with applications to materials processing, and plasma-nanocluster interactions.

Fellow: Karl Umstadter



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